We have a new paper out in Chem. Sci.! Viraj shows that by modulating the strength of the aromatic stacking interactions governing folding, we can control the size of the macrocycle produced on self-assembly.
A new paper is out in Angew. Chem.! Lasith and Mosharraf review the transient covalent bond as a tool for designing nonequilibrium systems, including molecular machines and dissipative assemblies.
We have a new paper out in Org. Lett.! Isuru, Frank, Georgia, and Lasith show that diphenic acid derivatives undergo transient geometry changes on treatment with carbodiimide fuels.
A new paper is out in Eur. J. Org. Chem.! Viraj and our collaborators Briana Schrage and Chris Ziegler from the University of Akron study the assembly of hydrocarbon o-phenylene macrocycles assembled using olefin metathesis. We continue to learn more and more about assembling foldamers into more complex structures, and the molecules are particularly pretty.
We have a new paper out in Angew. Chem.! Mosharraf and Josh show that carbodiimide-fueled anhydride formation can be used to assemble macrocycles containing multiple transient bonds. We believe this will have significant implications for generating out-of-equilibrium species of increased structural complexity.
Many thanks to the editors for selecting this as a “Hot Paper”!
Our latest paper is out in Chemical Science! Zach and Viraj explore the interplay between folding and macrocyclization with ortho-phenylene hexamers and decamers. Confinement within the macrocycle forces the foldamer into conformations that are typically not observed, which is predictable using simple computational models.
Our latest paper is out in J. Chem. Educ.! In collaboration with the Yezierski group, we have developed an undergraduate teaching lab on the self-assembly of macrocycles under thermodynamic control. The lab combined elements of experimental and computational chemistry to probe the importance of strain in these systems.
Our latest paper is out in Chemical Science! We demonstrate twist-sense control in o-phenylenes by attaching various chiral imines. Close examination of structure–property effects gives a very detailed mechanism for this process.